A liposome/gelatin methacrylate nanocomposite hydrogel system for delivery of stromal cell-derived factor-1α and stimulation of cell migration
作者: Justine R. YuMiriam JanssenBarry J. LiangHuang-Chiao HuangJohn P. Fisher
作者单位: 1Fischell Department of Bioengineering, University of Maryland – College Park, 3121 A. James Clark Hall, 8278 Paint Branch Drive, College Park, MD 20742, United States
2NIH/NBIB Center for Engineering Complex Tissues, University of Maryland – College Park, 3121 A. James Clark Hall, 8278 Paint Branch Drive, College Park, MD 20742, United States
3University of Maryland School of Medicine, Baltimore, MD 21201, United States
4Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, United States
刊名: Acta Biomaterialia, 2020
来源数据库: Elsevier Journal
DOI: 10.1016/j.actbio.2020.03.015
关键词: LiposomeNanocomposite hydrogelMesenchymal stem cellMigration
原始语种摘要: Abstract(#br)Chronic, non-healing skin and soft tissue wounds are susceptible to infection, difficult to treat clinically, and can severely reduce a patient's quality of life. A key aspect of this issue is the impaired recruitment of mesenchymal stem cells (MSCs), which secrete regenerative cytokines and modulate the phenotypes of other effector cells that promote healing. We have engineered a therapeutic delivery system that can controllably release the pro-healing chemokine stromal cell derived factor-1α (SDF-1α) to induce the migration of MSCs. In order to protect the protein cargo from hydrolytic degradation and control its release, we have loaded SDF-1α in anionic liposomes (lipoSDF) and embedded them in gelatin methacrylate (GelMA) to form a nanocomposite hydrogel. In this study, we...
全文获取路径: Elsevier  (合作)
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影响因子:5.093 (2012)

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关键词翻译
关键词翻译
  • hydrogel 水凝胶
  • gelatin 
  • delivery 移交
  • stimulation 激励
  • methacrylate 甲基丙烯酸酯
  • liposome 脂质体
  • migration 迁移
  • derived 导生的
  • stromal 基质的
  • healing 加硫