Do magnetic resonance imaging manifestations of skeletal system improve after treatment of Gaucher disease?
骨骼系统的磁共振影像学表现在戈彻病治疗后有改善吗?
作者: Di LiXiaojuan TaoNingning ZhangAihua HuoHuiying KangChen XuYonghong ZhangYun Peng
作者单位: 1Department of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045 China
2Department of Hematology, Beijing Children’s Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045 China
刊名: European Journal of Radiology, 2020, Vol.125
来源数据库: Elsevier Journal
DOI: 10.1016/j.ejrad.2020.108851
关键词: Gaucher diseaseSkeletalMagnetic resonance imaging
原始语种摘要: Abstract(#br)Objectives(#br)Skeletal lesions are the most serious complications of Gaucher disease (GD). The pathological changes of skeletal system are complex, which seriously affects the quality of life. The aim was to investigate whether the skeletal system improved in quantitative imaging after treatment with enzyme replacement therapy (ERT).(#br)Methods(#br)Magnetic resonance imaging (MRI) of the vertebrae and femur was performed in 40 patients and 34 healthy volunteers. The scan sequences include iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation (IDEAL-IQ) and intravoxel incoherent motion imaging (IVIM). Statistical data were analyzed by using t -test.(#br)Results(#br)As for the fat fraction (FF) and R2*, there were significant...
全文获取路径: Elsevier  (合作)
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来源刊物:
影响因子:2.512 (2012)

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关键词翻译
关键词翻译
  • system 
  • imaging 图像形成
  • resonance 共振
  • improved 改进
  • seriously 严重地
  • skeletal 骨架
  • vertebrae 
  • femur 股骨
  • treatment 处理
  • apparent 外观上的