Three different types of solubilization of thymol in Tween 80: Micelles, solutions, and emulsions- a mechanism study of micellar solubilization
作者: Cheng WangYu YangXiaohong CuiShangwu DingZhong Chen
作者单位: 1Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, China
2Department of Chemistry and Center for Nanoscience and Nanotechnology, National Sun Yat-sen University, Kaohsiung, Taiwan
刊名: Journal of Molecular Liquids, 2020, Vol.306
来源数据库: Elsevier Journal
DOI: 10.1016/j.molliq.2020.112901
关键词: Micellar solubilizationProcess and mechanism2D DOSYMicellesSolution solubilizationEmulsions
英文摘要: Abstract(#br)The micellar solubilization process and mechanism with thymol and Tween 80 as the model drug and surfactant were studied by the tensiometric study, 1 H NMR spectroscopy, 2D diffusion ordered spectroscopy (DOSY) and NOESY. First of all, changes in chemical shifts and line shapes of thymol and Tween 80 in mixed solutions compared with those in pure solutions, the co-diffusion of thymol and Tween 80 molecules, and cross peaks between them prove that thymol molecules are solubilized in Tween 80 micelles. The thymol-incorporated Tween 80 micelles form, and its critical micellar concentration (CMC) was obtained. Almost synchronously, the independent diffusion of thymol molecules was observed. These indicate that when the CMC of thymol-incorporated Tween 80 micelles is reached, a...
全文获取路径: Elsevier  (合作)
影响因子:1.684 (2012)

  • solubilization 加溶
  • thymol 百里酚
  • Tween 吐温
  • study 学习
  • mechanism 机构
  • micellar 胶束的
  • different 不相同的