Alcohol-Mediated Renal Denervation Using the Peregrine System Infusion Catheter for Treatment of Hypertension
作者: Felix MahfoudJean RenkinHorst SievertStefan BertogSebastian EwenMichael BöhmJean-Philippe LengeléWojciech WojakowskiRoland SchmiederMarkus van der GietHelen PariseNicole HarataniAtul PathakAlexandre Persu
作者单位: 1Department of Internal Medicine III, Cardiology, Angiology, Intensive Care Medicine, Saarland University Medical Center, Homburg, Germany
2Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires Saint-Luc and Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium
3CardioVascular Center Frankfurt, Frankfurt, Germany
4Anglia Ruskin University, Chelmsford, United Kingdom
5University California, San Francisco, San Francisco, California
6Yunnan Hospital Fuwai, Kunming, China
7Medical University of Silesia, Katowice, Poland
8University Hospital Erlangen, Friedrich-Alexander University Erlangen, Erlangen, Germany
9Department of Nephrology and Intensive Care Medicine, Charité–Universitätsmedizin Berlin, Germany
10Las Vegas, Nevada
11Ablative Solutions, San Jose, California
12Department of Cardiovascular Medicine, Hypertension and Heart Failure Unit, INSERM 1048, Clinique Pasteur, Toulouse, France
刊名: JACC: Cardiovascular Interventions, 2020, Vol.13 (4), pp.471-484
来源数据库: Elsevier Journal
DOI: 10.1016/j.jcin.2019.10.048
关键词: AlcoholCatheterHypertensionNeurolysisRenal denervation
原始语种摘要: Abstract(#br)Objectives(#br)The aim of this multicenter, open-label trial was to evaluate the safety and efficacy of alcohol-mediated renal denervation using a novel catheter system (the Peregrine System Infusion Catheter) for the infusion of dehydrated alcohol as a neurolytic agent into the renal periarterial space.(#br)Background(#br)The number of hypertensive patients with uncontrolled blood pressure (BP) remains unacceptably high. The renal sympathetic nervous system has been identified as an attractive therapeutic target.(#br)Methods(#br)Forty-five patients with uncontrolled hypertension on ≥3 antihypertensive medications underwent bilateral renal denervation using the Peregrine Catheter with 0.6 ml alcohol infused per renal artery.(#br)Results(#br)All patients were treated as...
全文获取路径: Elsevier  (合作)
影响因子:6.552 (2012)