Knockout of farnesoid X receptor aggravates process of diabetic cardiomyopathy
farnesoid X受体基因敲除对糖尿病心肌病加重过程的影响
作者: Sujing QiangLingyun TaoJie ZhouQianwan WangKesheng WangMeiling LuWeifeng WangLin HanShaobo XueYan ChenHuanhuan ZhuZheng LiuYue Zhang
作者单位: 1Department of Central Laboratory, Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, China
2Shanghai Laboratory Animal Research Center, Shanghai 201203, China
3Department of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, China
4Department of Cardiology, Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, China
刊名: Diabetes Research and Clinical Practice, 2020, Vol.161
来源数据库: Elsevier Journal
DOI: 10.1016/j.diabres.2020.108033
关键词: FXRDiabetic cardiomyopathyCardiac fibrosisLipid accumulation
英文摘要: Abstract(#br)Previous studies have shown that FXR is involved in glycolipid metabolism, tissue inflammation and regeneration in organs such as the liver, intestines and kidneys. Although FXR has been reported in cardiac tissue, its function in diabetic cardiomyopathy has not been reported. Here, we successfully constructed a diabetic mouse model of FXR −/− and evaluated the effects of FXR knockout on cardiac function in mice by measuring various indicators. We demonstrated that blood glucose levels in diabetic mice are significantly elevated in the case of FXR knockout. Our findings from cardiac ultrasound and tissue HE staining supported that FXR knockout aggravates diabetic cardiomyopathy. Masson staining of myocardial tissue and quantitative detection of α-SMA by qPCR suggest that FXR...
全文获取路径: Elsevier  (合作)
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影响因子:2.741 (2012)

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关键词翻译
关键词翻译
  • cardiomyopathy 心肌病
  • diabetic 糖尿病患者
  • fibrosis 纤维化
  • receptor 接受体
  • accumulation 堆积
  • process 过程