Crystal structure, DNA interaction and in vitro anticancer activity of Cu(II) and Pt(II) compounds based on benzimidazole-quinoline derivative
作者: Sen LiJin'an ZhaoBangpeng YuanXinyang WangJunshuai ZhangLiang YueHongwei HouJiyong HuShufang Chen
作者单位: 1College of Chemistry, Zhengzhou University, Zhengzhou 450001, Henan, PR China
2College of Material and Chemical Engineering, Henan University of Urban Construction, Pingdingshan 467036, Henan, PR China
刊名: Polyhedron, 2020, Vol.179
来源数据库: Elsevier Journal
DOI: 10.1016/j.poly.2020.114369
关键词: Benzimidazole-quinoline derivativePt(II) and Cu(II) compoundsDNA interactionApoptosisAnticancer
原始语种摘要: Abstract(#br)In this study, three transition metal compounds based on benzimidazole-quinoline ligand [Cu(pbmq)Cl 2 ] 2 (1) , [Cu(pbmq)Br 2 ] 2 (2) , and Pt(pbmq)Cl 2 (3) (where pbmq = 2-((2-(pyridin-2-yl)-1H-benzo[ d ]imidazol-1-yl)methyl)quinolone), were synthesized and characterized. The compounds showed much higher cytotoxicity than pbmq against the tested human cancer cell lines. Notably, compound 1 exhibited marked anticancer activity against SMMC7721 cells. Hence, compound 1 was selected for further studies to understand the underlying mechanisms of its anticancer activity. Fluorescence, CD spectroscopy studies and viscosity determination showed that compound 1 could strongly bind to calf thymus DNA (CT-DNA). The CT-DNA binding properties revealed that intercalation might be the...
全文获取路径: Elsevier  (合作)
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影响因子:1.813 (2012)

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关键词翻译
关键词翻译
  • quinoline 喹啉
  • II Interactive Interface
  • compounds 化合物
  • derivative 衍生物
  • interaction 相互酌
  • activity 活度
  • benzimidazole 苯并咪唑
  • DNA Deoxyribonucleic Acid
  • anticancer 抗癌的
  • based 基于