Fibroblast Activation Protein Regulates Lesion Burden and the Fibroinflammatory Response in Apoe -Deficient Mice in a Sexually Dimorphic Manner
作者: James MonslowLeslie ToddJohn E. ChojnowskiPriya K. GovindarajuRichard K. AssoianEllen Puré
作者单位: 1Department of Biomedical Sciences, University of Pennsylvania, Philadelphia Pennsylvania
2Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia Pennsylvania
刊名: The American Journal of Pathology, 2020, Vol.190 (5), pp.1118-1136
来源数据库: Elsevier Journal
DOI: 10.1016/j.ajpath.2020.01.004
英文摘要: Fibroblast activation protein (FAP) has been established as an inducible and mesenchymal cell-specific mediator of disease progression in cancer and fibrosis. Atherosclerosis is a fibroinflammatory disease, and FAP was previously reported to be up-regulated in human atherosclerotic plaques compared with normal vessel. We investigated the spatial and temporal distribution of Fap-expressing cells in a murine model of atherosclerosis and used a genetic approach to determine if and how Fap affected disease progression. Fap was found to be expressed predominantly on vascular smooth muscle cells in lesions of athero-prone Apoe −/− mice. Global deletion of Fap ( Fap −/− ) in Apoe −/− mice accelerated atherosclerotic disease progression in both males and females, with the effect observed earlier...
全文获取路径: Elsevier  (合作)
影响因子:4.522 (2012)