High glypican-3 expression characterizes a distinct subset of ovarian clear cell carcinomas in Canadian patients: an opportunity for targeted therapy
作者: Katharina WiedemeyerMartin KöbelHolly KoelkebeckZhan XiaoKapil Vashisht
作者单位: 1Department of Pathology and Laboratory Medicine, University of Calgary, And Alberta Public Laboratories, Calgary, Alberta, Canada
2AstraZeneca, One MedImmune Way, Gaithersburg, Maryland, 20878, USA
刊名: Human Pathology, 2020, Vol.98 , pp.56-63
来源数据库: Elsevier Journal
DOI: 10.1016/j.humpath.2020.01.002
关键词: Ovarian cancerClear cell carcinomaOncofetalGPC3GlypicanImmunotherapy
英文摘要: Summary(#br)The expression frequency and distribution of glypican-3 (GPC3) was retrospectively assessed by immunohistochemistry in 316 accurately phenotyped ovarian clear cell carcinoma (OCCC) specimens from Canadian patients. The study aimed to evaluate the prevalence of this biomarker in OCCC in a mixed-ethnicity Canadian population and to evaluate associations of GPC3 expression with clinicopathological parameters. Tissue microarrays with napsin A or HNF1β positive and WT1-negative OCCC specimens were evaluated using a GPC3 antibody clone 1G12. Membranous, cytoplasmic, and Golgi pattern GPC3 expression was noted in 184 of 316 (58.2%) cases; 63 of 316 (20%) cases showed high GPC3 expression (>50% of tumor cells were positive). GPC3 expression was not associated with age, stage, and...
全文获取路径: Elsevier  (合作)
影响因子:2.843 (2012)

  • distinct 相异的
  • expression 表示
  • targeted 对准目标的
  • opportunity 机会
  • ovarian 卵巢的
  • subset 子集
  • clear 昧的
  • Canadian 加拿大的
  • therapy 治疗