CircHIPK3 promotes colorectal cancer cells proliferation and metastasis via modulating of miR-1207-5p/FMNL2 signal
作者: Yan YanMeng SuBaoli Qin
作者单位: 1Department of Medical Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, PR China
刊名: Biochemical and Biophysical Research Communications, 2020, Vol.524 (4), pp.839-846
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbrc.2020.01.055
关键词: CircHIPK3FMNL2MiR-1207-5pProliferation/metastasisColorectal cancer
原始语种摘要: Abstract(#br)Increasing evidences demonstrate that circular RNAs (circRNAs) are extensively implicated in various cancers including colorectal cancer (CRC). In the present study, we found that circRNA HIPK3 (circPIK3) was upregulated in CRC. We identified that circHIPK3 was closely related with unfavorable clinicopathological features in patients with CRC. Functional transwell assay and proliferation assay indicated that circHIPK3 served as an oncogene and promoted CRC cells migration, invasion and proliferation. Meanwhile, we found that formin like 2 (FMNL2) was a key downstream molecule in circHIPK3-induced metastasis and proliferation in CRC cells. We further verified that circHIPK3 was mainly located at cytoplasm through an immunofluorescence assay. An online bioinformatics screening...
全文获取路径: Elsevier  (合作)

  • colorectal 结肠直肠的
  • metastasis 同质蜕变
  • modulating 调制的
  • cells 麻风细胞
  • cancer 癌症
  • proliferation 增生
  • signal 信号