Biological coating with platelet-rich plasma and adipose tissue-derived microvascular fragments improves the vascularization, biocompatibility and tissue incorporation of porous polyethylene
作者: Thomas SpäterAnne L. TobiasMaximilian M. MengerRuth M. NickelsMichael D. MengerMatthias W. Laschke
作者单位: 1Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg/Saar, Germany
2Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421 Homburg/Saar, Germany
刊名: Acta Biomaterialia, 2020
来源数据库: Elsevier Journal
DOI: 10.1016/j.actbio.2020.03.018
关键词: Porous polyethyleneMedpor®Microvascular fragmentsVascularizationBiocompatibility
原始语种摘要: Abstract(#br)Porous polyethylene (pPE) is a commonly used biomaterial in craniofacial reconstructive surgery. However, implant failure due to insufficient vascularization represents a major issue. To overcome this problem, we herein introduce an effective strategy to improve the vascularization and incorporation of pPE. Adipose tissue-derived microvascular fragments (MVF) from transgenic green fluorescent protein (GFP) + mice were suspended in platelet-rich plasma (PRP) for the coating of pPE. PRP/MVF-coated pPE as well as PRP-coated and uncoated controls were subsequently implanted into the dorsal skinfold chamber and the flanks of GFP − wild-type mice to analyze their in vivo performance throughout 2, 4 and 8 weeks by means of intravital fluorescence microscopy, histology and...
全文获取路径: Elsevier  (合作)
影响因子:5.093 (2012)

  • incorporation 掺合
  • microvascular 微脉管(直径小于0.3 毫米的微血管)的
  • biomaterial 生物材料
  • tissue 组织
  • coating 覆盖层
  • polyethylene 聚乙烯
  • derived 导生的
  • controls 控制机构
  • macrophage 巨噬细胞
  • coated 涂渍的