Biological coating with platelet-rich plasma and adipose tissue-derived microvascular fragments improves the vascularization, biocompatibility and tissue incorporation of porous polyethylene
富含血小板血浆和脂肪组织来源的微血管碎片的生物涂层改善了多孔聚乙烯的血管化、生物相容性和组织掺入
作者: Thomas SpäterAnne L. TobiasMaximilian M. MengerRuth M. NickelsMichael D. MengerMatthias W. Laschke
作者单位: 1Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg/Saar, Germany
2Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421 Homburg/Saar, Germany
刊名: Acta Biomaterialia, 2020
来源数据库: Elsevier Journal
DOI: 10.1016/j.actbio.2020.03.018
关键词: Porous polyethyleneMedpor®Microvascular fragmentsVascularizationBiocompatibility
原始语种摘要: Abstract(#br)Porous polyethylene (pPE) is a commonly used biomaterial in craniofacial reconstructive surgery. However, implant failure due to insufficient vascularization represents a major issue. To overcome this problem, we herein introduce an effective strategy to improve the vascularization and incorporation of pPE. Adipose tissue-derived microvascular fragments (MVF) from transgenic green fluorescent protein (GFP) + mice were suspended in platelet-rich plasma (PRP) for the coating of pPE. PRP/MVF-coated pPE as well as PRP-coated and uncoated controls were subsequently implanted into the dorsal skinfold chamber and the flanks of GFP − wild-type mice to analyze their in vivo performance throughout 2, 4 and 8 weeks by means of intravital fluorescence microscopy, histology and...
全文获取路径: Elsevier  (合作)
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来源刊物:
影响因子:5.093 (2012)

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关键词翻译
关键词翻译
  • incorporation 掺合
  • microvascular 微脉管(直径小于0.3 毫米的微血管)的
  • biomaterial 生物材料
  • tissue 组织
  • coating 覆盖层
  • polyethylene 聚乙烯
  • derived 导生的
  • controls 控制机构
  • macrophage 巨噬细胞
  • coated 涂渍的