Pharmacokinetics of danofloxacin in rainbow trout after different routes of administration
达诺沙星在虹鳟不同给药途径后的药代动力学研究
作者: Ertugrul TerziOrhan CorumSoner BilenOsman Nezih KenanogluOrkun AtikKamil Uney
作者单位: 1Faculty of Fisheries, University of Kastamonu, Kastamonu 37200, Turkey
2Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Kastamonu, Kastamonu 37200, Turkey
3Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Afyon Kocatepe, 03200, Afyonkarahisar, Turkey
4Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya 42031, Turkey
刊名: Aquaculture, 2020, Vol.520
来源数据库: Elsevier Journal
DOI: 10.1016/j.aquaculture.2020.734984
关键词: PharmacokineticsPharmacodynamicsDanofloxacinRainbow trout
英文摘要: Abstract(#br)The pharmacokinetics of danofloxacin was studied in rainbow trout ( Oncorhynchus mykiss ) after single administration by intravenous (IV), intramuscular (IM) and oral (OR) gavage at a dose of 10 mg/kg and by 10 mg/L bath for 2 h at 11.7 ± 0.8 °C. Furthermore, minimal inhibitory concentrations (MICs) of danofloxacin against a pathogenic strain of Yersinia ruckeri , Pseudomonas spp., and Aeromonas hydrophila were determined. Plasma concentrations of danofloxacin were determined using high-performance liquid chromatograph - UV and further subjected to noncompartmental analysis. Elimination half-lives for IV, IM, OR and bath administration were 25.97 h, 42.43 h, 41.04 h and 40.41 h, respectively. Peak plasma concentrations (C max ) for IM, OR and bath administration were 3.64 ±...
全文获取路径: Elsevier  (合作)
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影响因子:2.009 (2012)

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关键词翻译
关键词翻译
  • trout 
  • rainbow 
  • Rainbow 虹牌纤维
  • different 不相同的
  • administration 管理
  • after 在之后