Something old, something new: liver injury associated with total parenteral nutrition therapy and immune checkpoint inhibitors
一些旧的,一些新的:与全肠外营养疗法和免疫检查点抑制剂相关的肝损伤
作者: Cherise MeyersonBita V. Naini
作者单位: 1Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1732, USA
刊名: Human Pathology, 2020, Vol.96 , pp.39-47
来源数据库: Elsevier Journal
DOI: 10.1016/j.humpath.2019.10.007
关键词: Total parenteral nutrition (TPN)Intestinal failure–associated liver disease (IFALD)Liver injuryCholestasisSteatosisImmune checkpoint inhibitor (ICI)ICI-induced hepatitis
英文摘要: Summary(#br)Drug-induced liver injury (DILI) is a challenging and constantly changing field. The pathologist plays a key role in interpreting liver biopsies by classifying the pattern of injury, grading the severity of injury, and evaluating for other possible causes. Reports of iatrogenic liver injury are reviewed here with a focus on total parenteral nutrition (ie, intestinal failure–associated liver disease [IFALD]) and immune checkpoint inhibitors (ICIs). The hallmark features of IFALD are cholestasis and steatosis. Cholestasis is more common in infants, whereas steatosis and steatohepatitis are more commonly seen in older children and adults. Infants tend to have a faster progression to fibrosis and cirrhosis. Perivenular fibrosis and ductopenia may also be seen in IFALD. Although...
全文获取路径: Elsevier  (合作)
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影响因子:2.843 (2012)

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关键词翻译
关键词翻译
  • parenteral 不经肠的
  • nutrition 营养
  • liver 
  • associated 相关的
  • checkpoint 检查地点
  • immune 免疫的
  • injury 损害
  • TPN 全肠外营养
  • hepatitis 肝炎
  • therapy 治疗