circCELSR1 (hsa_circ_0063809) Contributes to Paclitaxel Resistance of Ovarian Cancer Cells by Regulating FOXR2 Expression via miR-1252
作者: Shu ZhangJie ChengChenlian QuanHao WenZheng FengQin HuJun ZhuYan HuangXiaohua Wu
作者单位: 1Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Shanghai 200000, China
刊名: Molecular Therapy - Nucleic Acids, 2020, Vol.19 , pp.718-730
来源数据库: Elsevier Journal
DOI: 10.1016/j.omtn.2019.12.005
关键词: Circular RNACELSR1MicroRNAResistanceGrowth ovarian cancer
原始语种摘要: Ovarian cancer is the malignant tumor of the female reproductive system with the highest fatality rate. Tolerance to chemotherapeutic drugs such as paclitaxel (PTX) occurring in the very early stage is one of the important factors of the poor prognosis of ovarian cancer. Herein, we aim to study the dysregulation of a particular circular RNA (circRNA), circCELSR1 (hsa_circ_0063809), and its role in the progression and PTX resistance of ovarian cancer. The high expression of circCELSR1 in PTX-resistant tissues of ovarian cancer and PTX-resistant ovarian cancer cells (SKOV3/PTX and HeyA-8/PTX) was determined by microarray analyses and quantitative real-time PCR. Cell Counting Kit-8 (CCK-8) assays were performed to investigate the effect of circCELSR1 on PTX sensitivity of ovarian cancer...
全文获取路径: Elsevier  (合作)