Complement Membrane Attack Complex
作者: Catherine B. XieDan Jane-WitJordan S. Pober
作者单位: 1Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut
2Division of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut
刊名: The American Journal of Pathology, 2020
来源数据库: Elsevier Journal
DOI: 10.1016/j.ajpath.2020.02.006
英文摘要: The complement membrane attack complex (MAC) is classically known as a cytolytic effector of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or targeted cells, leading to osmolysis. Nucleated cells resist MAC-mediated cytolysis by expression of inhibitors that block MAC assembly or by rapid removal of MAC through endocytosis or shedding. In the absence of lysis, MAC may induce intracellular signaling and cell activation, responses implicated in a variety of autoimmune, inflammatory, and transplant disease settings. New discoveries into the structure and biophysical properties of MAC revealed heterogeneous MAC precursors and conformations that provide insights into MAC function. In addition, new mechanisms of MAC-mediated signaling and its contribution to...
全文获取路径: Elsevier  (合作)
影响因子:4.522 (2012)