Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure
作者: Douglas S LeeQuang T NguyenNathalie LapointePeter C AustinArne OhlssonJack V TuDuncan J StewartJean L Rouleau
作者单位: 1From the Departments of 1 Department of Medicine University of Toronto, Toronto, Canada and 2 Department of Health Policy, Management and Evaluation/Clinical Epidemiology, University of Toronto, Toronto, Canada; 3 University Health Network, Toronto General Hospital, Toronto, Canada, 4 Institute for Clinical Evaluative Sciences, Toronto, Canada; 5 Department of Paediatrics, Mount Sinai Hospital, Toronto, Canada; 6 Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada; and 7 Division of Cardiology, St. Michael’s Hospital, Toronto, Canada
刊名: Journal of Cardiac Failure, 2003, Vol.9 (5), pp.368-374
来源数据库: Elsevier Journal
DOI: 10.1054/S1071-9164(03)00125-8
关键词: Heart failureMyocardial infarctionMeta-analysisClinical trialsStatisticsMortalityPrediction
原始语种摘要: Abstract(#br)Background(#br)Although an initial study of endothelin receptor blockade reported positive findings, subsequent experiments and clinical trials in humans found little or no benefit.(#br)Methods(#br)We applied meta-analytic methods to assess the methodologic rigor of preclinical studies of endothelin blockade and to quantitatively evaluate the totality of evidence regarding the effect of endothelin receptor blockers in experimental heart failure. A total of 396 animals were assigned to control and 594 were assigned to experimental therapy in the pooled analysis. Of the 9 studies identified, no study reported a priori sample size justification. Although there was a tendency to increased mortality with early administration (relative risk 1.39, P =...
全文获取路径: Elsevier  (合作)
影响因子:3.32 (2012)

  • endothelin 内皮缩血管肽
  • blockade 封闭
  • experimental 实验的
  • receptor 接受体
  • failure 破坏
  • heart 心脏
  • analysis 分析
  • survival 生存
  • preclinical 临证前期的
  • effects 海员自身物品