Design, preparation and evaluation of different branched biotin modified liposomes for targeting breast cancer
作者: Baolan TangYao PengQiming YueYanchi PuRu LiYi ZhaoLi HaiLi GuoYong Wu
作者单位: 1Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China
2Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China
刊名: European Journal of Medicinal Chemistry, 2020, Vol.193
来源数据库: Elsevier Journal
DOI: 10.1016/j.ejmech.2020.112204
关键词: BiotinActive targeting ligandBreast cancerDrug deliveryLiposome
英文摘要: Abstract(#br)A series of liposome ligands (Bio-Chol, Bio-Bio-Chol, tri-Bio-Chol and tetra-Bio-Chol) modified by different branched biotins that can recognize the SMVT receptors over-expressed in breast cancer cells were synthesized. And four liposomes (Bio-Lip, Bio-Bio-Lip, tri-Bio-Lip and tetra-Bio-Lip) modified by above mentioned ligands as well as the unmodified liposome (Lip) were prepared to study the targeting ability for breast cancer. The cytotoxicity study and apoptosis assay of paclitaxel-loaded liposomes showed that tri-Bio-Lip had the strongest anti-proliferative effect on breast cancer cells. The cellular uptake studies on mice breast cancer cells (4T1) and human breast cancer cells (MCF-7) indicated tri-Bio-Lip possessed the strongest internalization ability, which was 5.21...
全文获取路径: Elsevier  (合作)
影响因子:3.499 (2012)

  • targeting 导向目标
  • branched 分枝的
  • breast 胸部
  • cancer 癌症
  • biotin 生物素
  • different 不相同的
  • preparation 预备
  • evaluation 评价
  • modified 改进