Near-infrared/pH dual-responsive nanocomplexes for targeted imaging and chemo/gene/photothermal tri-therapies of non-small cell lung cancer
近红外/ pH双响应纳米复合物用于靶向成像和非小细胞肺癌的化学/基因/光热三联疗法
作者: Ziying LiLisheng ZhuWeiqun LiuYilin ZhengXudong LiJinxiang YeBifei LiHaijun ChenYu Gao
作者单位: 1Cancer Metastasis Alert and Prevention Center, College of Chemistry, Fuzhou University, 2 Xueyuan Road, Yangguang Building, 6FL, Fuzhou 350108, China
2Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, China
刊名: Acta Biomaterialia, 2020, Vol.107 , pp.242-259
来源数据库: Elsevier Journal
DOI: 10.1016/j.actbio.2020.03.004
关键词: ErlotinibGene therapyPhotothermal therapyChitosanNSCLC
原始语种摘要: Abstract(#br)Combination therapy offers promising opportunities for treating advanced non-small cell lung cancer (NSCLC). Here, we established a chitosan-based nanocomplex CE7Q/CQ/S to deliver molecular-targeted drug erlotinib (Er), Survivin shRNA-expressing plasmid (SV), and photothermal agent heptamethine cyanine dye (Cy7) in one platform for simultaneous near-infrared (NIR) fluorescence imaging and triple-combination therapy of NSCLC bearing epidermal growth factor receptor (EGFR) mutations. The obtained CE7Q/CQ/S exhibited favorable photothermal effects, good DNA binding ability, and pH/NIR dual-responsive release behaviors. The conjugated Er could mediate specific delivery of Cy7 to EGFR-mutated NSCLC cells to enable targeted NIR fluorescence imaging and photothermal therapy (PTT)....
全文获取路径: Elsevier  (合作)
影响因子:5.093 (2012)

  • chemo 表示化学的
  • targeted 对准目标的
  • cancer 癌症
  • chitosan 壳聚糖
  • imaging 图像形成
  • responsive 承担责任
  • epidermal 上皮的
  • survival 生存
  • favorable 好意的
  • therapeutic 治疗的