Effects of progesterone treatment on endothelium-dependent coronary relaxation in ovariectomized rats
作者: Tagana Rosa da CunhaJéssyca Aparecida Soares GiesenWender Nascimento RouverEduardo Damasceno CostaMarcella Daruge GrandoVirgínia Soares LemosLusiane Maria BendhackRoger Lyrio dos Santos
作者单位: 1Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES, Brazil
2Department of Physiology and Biophysics, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
3Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil
刊名: Life Sciences, 2020, Vol.247
来源数据库: Elsevier Journal
DOI: 10.1016/j.lfs.2020.117391
关键词: ProgesteroneEndotheliumOvariectomized ratsCoronary reactivity
原始语种摘要: Abstract(#br)Aim(#br)Although progesterone (P4) has a beneficial effect on the cardiovascular system, P4 actions on the coronary bed have not yet been fully elucidated. This study evaluated the effect of progesterone treatment on endothelium-dependent coronary vascular reactivity in Wistar rats.(#br)Main methods(#br)Eight-week-old adult rats were divided into Sham, Ovariectomized (OVX), Ovariectomized and progesterone treated (OVX P4). The OVX P4 group received daily doses of progesterone (2 mg/kg/day). Vascular reactivity was assessed by a modified Langendorff technique. The intensity of eNOS, Akt , and gp91phox protein expression was quantified by Western blotting. Superoxide anion (O 2 ●- ) and hydrogen peroxide (H 2 O 2 ) production was measured by dihydroethidium and...
全文获取路径: Elsevier  (合作)
影响因子:2.555 (2012)

  • ovariectomized 切除卵巢的
  • coronary 冠状的
  • progesterone 孕酮
  • endothelium 内皮
  • relaxation 松弛
  • treatment 处理
  • dependent 从属的
  • reactivity 反应性