Gold nanobipyramid-loaded black phosphorus nanosheets for plasmon-enhanced photodynamic and photothermal therapy of deep-seated orthotopic lung tumors
作者: Jing WangHan ZhangXiao XiaoDong LiangXinyue LiangLan MiJianfang WangJun Liu
作者单位: 1State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, PR China
2Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, PR China
3Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra-precision Optical Manufacturing, Fudan University, Shanghai 200433, PR China
4Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China
刊名: Acta Biomaterialia, 2020, Vol.107 , pp.260-271
来源数据库: Elsevier Journal
DOI: 10.1016/j.actbio.2020.03.001
关键词: Photodynamic therapyPhotothermal therapyLung cancerBlack phosphorus nanosheetsGold nanobipyramids
原始语种摘要: Abstract(#br)Various types of photodynamic agents have been explored for photodynamic therapy (PDT) to destroy cancers located in deep tissues. However, these agents are generally limited by low singlet oxygen ( 1 O 2 ) yields owing to weak absorption in the optical transparent window of biological tissues. Accordingly, in this work, we developed a nanocomposite through the assembly of gold nanobipyramids (GNBPs) on black phosphorus nanosheets (BPNSs). This nanocomposite could simultaneously enhance 1 O 2 generation and hyperthermia by localized surface plasmon resonance in cancer therapy. As two-dimensional inorganic photosensitizers, BPNSs were hybridized with GNBPs to form BPNS-GNBP hybrid nanosheets. The hybridization markedly increased 1 O 2 production by the BPNSs through...
全文获取路径: Elsevier  (合作)
影响因子:5.093 (2012)

  • phosphorus 
  • enhanced 增强
  • orthotopic 常位的
  • plasmon 细胞质基因
  • simultaneous 同时的
  • photodynamic 在光中发荧光的
  • promising 前提
  • black 炭黑
  • phototherapy 光线疗法
  • biological 生物学的