The efficacy and safety of probiotics in patients with irritable bowel syndrome: Evidence based on 35 randomized controlled trials
作者: Heng-Li NiuJi-Yuan Xiao
作者单位: 1Clinical Pharmacy Department, Lanzhou University Second Hospital, Lanzhou, 730030, China
刊名: International Journal of Surgery, 2020, Vol.75 , pp.116-127
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijsu.2020.01.142
关键词: ProbioticsIrritable bowel syndromeEfficacySafety
英文摘要: Abstract(#br)Background & objectives(#br)Irritable bowel syndrome (IBS) is a functional bowel disorder that may involve disturbance of the gastrointestinal microbiota. We performed a systematic review and meta-analysis of the efficacy and safety of probiotics in patients with IBS.(#br)Methods(#br)We searched the Cochrane Library, PubMed, EMBASE and Web of Science databases up to 1 April, 2019. Randomized controlled trials (RCTs) involving adults with IBS that compared probiotics to placebo or no therapy were eligible for the analysis. Dichotomous symptom data were pooled to calculate the relative risk (RR) with a 95% confidence interval (CI) of remaining symptoms after therapy. Continuous data were pooled using a standardized mean difference (SMD) with the 95% CI. Two reviewers assessed...
全文获取路径: Elsevier  (合作)
影响因子:1.436 (2012)

  • irritable 易发怒的
  • controlled 受控
  • bowel 
  • efficacy 效验
  • syndrome 症候群
  • safety 安全
  • based 基于