Convergent syndromic atrophy of pain and emotional systems in patients with irritable bowel syndrome and depressive symptoms
作者: Jie LiBinke YuanGuoxiong LiXingqi LuYun GuoYing YangMinjie LiangJianping DingQuan Zhou
作者单位: 1Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China
2Department of Radiology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China
3Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen, Guangdong, China
4Department of Gastroenterology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China
5Department of Radiology, Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics Guangdong Province), Guangzhou, Guangdong, China
刊名: Neuroscience Letters, 2020, Vol.723
来源数据库: Elsevier Journal
DOI: 10.1016/j.neulet.2020.134865
关键词: Irritable bowel syndromeDepressionBrain-gut axisStructural MRIVoxel-based morphometry
原始语种摘要: Abstract(#br)Irritable bowel syndrome (IBS) is a brain-gut disorder that is often accompanied by psychiatric comorbidities, particularly depression. However, the neuroanatomical substrates of IBS with depressive symptoms (DEP-IBS) and how depressive symptoms and brain morphology modulate IBS symptoms remain unknown. In this study, structural MRI data were processed using a voxel-based morphometry technique and one-way analysis of covariance (ANCOVA) and post-hoc t -tests were performed to compare gray matter volume (GMV) among 28 patients with DEP-IBS, 21 patients with IBS who lacked depressive symptoms (nDEP-IBS), and 36 healthy controls (HC). Correlation and mediation analyses were performed to evaluate the relationship between differing GMV in DEP-IBS and clinical variables. We found...
全文获取路径: Elsevier  (合作)
影响因子:2.026 (2012)

  • depressive 降低的
  • syndromic 综合症的
  • atrophy 萎缩
  • prefrontal 前额骨
  • irritable 易发怒的
  • depression 低地
  • bilateral 双边的
  • emotional 情绪的
  • striatal 纹状体的
  • morphometry 形态测定