Multi-instrumental approach to unravel molecular mechanisms of natural bioactive compounds: Case studies for flavonoids
多仪器方法揭示天然生物活性化合物的分子机制:黄酮类化合物的个案研究
作者: Gulyaim N. SagandykovaPaweł P. PomastowskiBogusław Buszewski
作者单位: 1Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarina 7, 87-100 Toruń, Poland
2Interdisciplinary Centre for Modern Technologies, Nicolaus Copernicus University, Wileńska 4, 87-100 Toruń, Poland
刊名: Trends in Analytical Chemistry, 2020, Vol.126
来源数据库: Elsevier Journal
DOI: 10.1016/j.trac.2020.115865
关键词: Natural compoundsInteractionsReceptorsSample preparationInstrumental techniquesMechanism
英文摘要: Abstract(#br)Flavonoids are natural compounds defined as plant secondary metabolites with various beneficial properties for human health that make them perspective drug candidates. However, research in this area should be deepened to collect reasonable amount of data to suggest biochemical mechanism of action that can be a key for evaluation of drug efficacy, side effects. In addition, from analytical point of view, analyte–receptor interaction is an interesting object for study as it includes challenges in sample preparation and analytical measurements. Thus, there is a need in modern instrumental analytical techniques for study of drug–receptor interactions. Combination of instrumental techniques represents multi-instrumental approach and provides an extended set of data to suggest...
全文获取路径: Elsevier  (合作)
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来源刊物:
影响因子:6.351 (2012)

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关键词翻译
关键词翻译
  • unravel 解开
  • bioactive 对活质起作用的
  • flavonoids 黄酮类似物
  • instrumental 仪器的
  • molecular 分子的
  • approach 
  • natural 自然的
  • compounds 化合物