Specific Deletion of p16 INK4a with Retention of p19 ARF Enhances the Development of Invasive Oral Squamous Cell Carcinoma
特异性缺失p16 INK4a并保留p19 ARF,增强侵袭性口腔鳞癌的发生发展
作者: Kazuhisa IshidaHiroyuki TomitaTomohiro KanayamaKei NoguchiAyumi NiwaMasaya KawaguchiMasafumi MiyaiMikiko MatsuoYuko ImaizumiKeizo KatoYuichiro HatanoAkihiro HirataHideshi OkadaToshiyuki ShibataAkira Hara
作者单位: 1Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan
2Department of Oral Maxillofacial Surgery, Gifu University Graduate School of Medicine, Gifu, Japan
3Department of Radiology, Gifu University Graduate School of Medicine, Gifu, Japan
4Department of Neuronal Surgery, Gifu University Graduate School of Medicine, Gifu, Japan
5Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
6Division of Animal Experiment, Life Science Research Center, Gifu University, Gifu, Japan
刊名: The American Journal of Pathology, 2020, Vol.190 (6), pp.1332-1342
来源数据库: Elsevier Journal
DOI: 10.1016/j.ajpath.2020.01.017
英文摘要: The cyclin-dependent kinase inhibitor 2A ( CDKN2A )/alternate reading frame (ARF) locus consists of two overlapping tumor suppressor genes, p16 INK4a and p14 ARF ( p19 ARF in mice), encoding two unrelated proteins in alternative reading frames. Previous reports suggest that p16 INK4a and p14 ARF alterations independently exhibit differential roles, and p16 INK4a is more closely associated with a poor prognosis in oral cancer. However, the role of p16 INK4a -specific loss in oral squamous cell carcinogenesis remains unclear. The authors assessed chemical carcinogen 4-nitroquinoline 1-oxide (4NQO)-induced multistep oral squamous cell carcinogenesis in mice carrying p16 INK4a -specific loss with retention of the p19 ARF gene ( p16 INK4a−/− ). 4NQO-treated p16 −/− mice exhibited a higher...
全文获取路径: Elsevier  (合作)
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影响因子:4.522 (2012)

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  • ARF Automatic Report Feature