Changes in myocardial gene expression associated with β-blocker therapy in patients with chronic heart failure
作者: Yoshio YasumuraKatsuya TakemuraAiji SakamotoMasafumi KitakazeKunio Miyatake
作者单位: 1From the 1 Division of Cardiology, Department of Medicine, National Cardiovascular Center, and 2 Division of Biotechnology, National Cardiovascular Center Research Institute, Osaka, Japan
刊名: Journal of Cardiac Failure, 2003, Vol.9 (6), pp.469-474
来源数据库: Elsevier Journal
DOI: 10.1016/S1071-9164(03)00581-5
关键词: Β-blockerMyocardial gene expressionHeart failure
原始语种摘要: Abstract(#br)Background(#br)The left ventricular functional recovery by β-blocker therapy is now attributed to time-dependent biologic effects on cardiomyocytes.(#br)Methods and results(#br)To elucidate the cellular mechanism of these biologic effects, we treated 9 patients with dilated cardiomyopathy for 4 months with β-blockers and examined the gene expressions linked to an improvement of left ventricular ejection fraction (EF). Gene expressions of the biopsied right ventricular endomyocardium were assessed by real-time reverse transcription-polymerase chain reaction. A decrease in β-myosin heavy chain (1.23±0.49 versus 0.86±0.45, P <.05) was observed 4 months after the administration of β-blockers. The expression levels of both sarcoplasmic reticulum Ca 2+ ATPase (SERCA) (0.80±0.28...
全文获取路径: Elsevier  (合作)
影响因子:3.32 (2012)

  • blocker 间苗器
  • expression 表示
  • myocardial 心肌的
  • failure 破坏
  • heart 心脏
  • phospholamban 受磷酸蛋白
  • adrenoreceptor 肾上腺素能受体
  • natriuretic 促尿钠排泄的
  • failing 缺点
  • ejection 喷出