Preclinical pharmacokinetics of M10 after intragastrical administration of M10-H and M10-Na in Wistar rats
大鼠灌胃M10-H和M10 Na后M10的临床前药代动力学
作者: Jiarui GaoGuifang DouXiaoxia ZhuHui GanRuolan GuZhuona WuTaoyun LiuSuxiang FengZhiyun Meng
作者单位: 1Department of Pharmaceutical Analysis, Henan University of Chinese Medicine, No. 156 Jinshui Road, Jinshui District, Zhengzhou 450046, China
2Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, No. 27 Taiping Road, Haidian District, Beijing 100850, China
刊名: Journal of Chromatography B, 2020, Vol.1140
来源数据库: Elsevier Journal
DOI: 10.1016/j.jchromb.2019.121905
关键词: M10PharmacokineticsUPLC-MS/MSMyricetin derivates
英文摘要: Abstract(#br)As a myricetin derivative, M10 is a potent agent of anti-chronic colonic inflammation. It has better activity than myricetin in preventing azoxymethane/dextran sulfate sodium - induced ulcerative colitis. Here, we introduce a sensitive quantification method based on ultra performance liquid chromatography-tandem mass spectrometry for the determination of M10-H and M10-Na in Wistar rat plasma. Samples were treated with L - ascorbic acid and phosphate buffer solution to maintain stability and with acetonitrile to remove the proteins in the plasma. The supernatant was separated with BEH C18 column and eluted with ultrapure water and acetonitrile both containing 0.1% formic acid. The detection was performed by a triple quadrupole mass spectrometer with positive electrospray...
全文获取路径: Elsevier  (合作)
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影响因子:2.487 (2012)

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