Influence of the ethanol/dichloromethane ratio on the preparation of microsponges composed of ethylcellulose and Eudragit or HPMCphthalate for hydrophilic drug delivery
作者: Mariana Volpato JunqueiraSabrina Célia CalçadoLidiane Vizioli de Castro-HoshinoMauro Luciano BaessoAnna Szarpak-JankowskaRachel Auzély-VeltyMarcos Luciano Bruschi
作者单位: 1Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, 87020-900 Maringa, Parana, Brazil
2Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringa, 87020-900 Maringa, Parana, Brazil
3Department of Physics, State University of Maringa, 87020-900 Maringa, Parana, Brazil
4Centre de Recherches sur les Macromolécules Végétales, Université Grenoble Alpes, Grenoble, France
刊名: Journal of Molecular Liquids, 2020, Vol.303
来源数据库: Elsevier Journal
DOI: 10.1016/j.molliq.2020.112633
关键词: EthylcelluloseEudragit RS1002-hydroxypropyl methylcellulose phthalateMethylene blueMicrospongesDrug delivery
原始语种摘要: Abstract(#br)Microsponges (MS) have shown great potential for the incorporation of relatively higher amounts of drugs. This is due to the presence of both surface pores and interconnected channels that provide a greater contact area for the absorption of active agents. However, the use of MS for carrying hydrophobic drugs is limited because the preparation methodology can totally remove hydrophilic drugs. Therefore, this work aimed to investigate possible changes in the proportion of organic solvents used to produce MS containing water-soluble drugs. A modified quasi -emulsion solvent diffusion technique was used to formulate MS with ethylcellulose and Eudragit RS 100 (MS-EE) or ethylcellulose and HPMCphthalate (MS-EH) using different combinations of ethanol/dichloromethane ratios. The...
全文获取路径: Elsevier  (合作)
影响因子:1.684 (2012)

  • ethylcellulose 乙基纤维素
  • delivery 移交
  • hydrophilic 亲水的
  • phthalate 邻苯二甲酸盐
  • ethanol 乙醇
  • preparation 预备
  • composed 沉着的
  • ratio