Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis
作者: Miguel Ángel González-MolesIsabel Ruiz-ÁvilaLucía González-RuizÁngela AyénJosé Antonio Gil-MontoyaPablo Ramos-García
作者单位: 1School of Dentistry, University of Granada, Granada, Spain
2Instituto de Investigación Biosanitaria. Granada, Spain
3Servicio de Anatomía Patológica, Complejo Hospitalario Universitario de Granada, Granada, Spain
4Servicio de Dermatología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
5School of Medicine, University of Granada, Granada, Spain
刊名: Oral Oncology, 2019, Vol.96 , pp.121-130
来源数据库: Elsevier Journal
DOI: 10.1016/j.oraloncology.2019.07.012
关键词: Oral cancerMalignant transformationOral lichen planusOral lichenoid lesionsMeta-analysis
英文摘要: Abstract(#br)Objectives(#br)To evaluate current evidence on the malignant transformation of oral lichen planus (OLP), oral lichenoid lesions (OLLs), and oral lichenoid reactions (LRs) and to determine the variables with greatest influence on cancer development.(#br)Material and methods(#br)We searched PubMed, Embase, Web of Science, and Scopus for studies published before November 2018. We evaluated the quality of studies (QUIPS tool). We carried out meta-analyses to fulfill our objectives. We examined the between-study heterogeneity and small-study effects, and conducted sensitivity studies and subgroup analyses.(#br)Results(#br)Inclusion criteria were met by 82 studies (26,742 patients. The combined malignant transformation rate was 1.14% for OLP (95% CI = 0.84–1.49), 1.88% for OLLs...
全文获取路径: Elsevier  (合作)
影响因子:2.695 (2012)

  • lichen 地衣植物
  • planus 平的
  • transformation 变换
  • analysis 分析
  • comprehensive 全面
  • review 复审
  • systematic 有系统的
  • cancer 癌症