CXCL12/CXCR4 axis in the microenvironment of solid tumors: A critical mediator of metastasis
实体肿瘤微环境中CXCL12 / CXCR4轴:转移的关键介质
作者: Keywan Mortezaee
作者单位: 1Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
刊名: Life Sciences, 2020, Vol.249
来源数据库: Elsevier Journal
DOI: 10.1016/j.lfs.2020.117534
关键词: C-X-C chemokine ligand 12 (CXCL12)CXCR4Tumor microenvironment (TME)Cancer cellCancer stem cell (CSC)Hypoxia
英文摘要: Abstract(#br)Tumors are dynamic tissue masses, so requiring continuous exposure to the host cells, nurturing them into pave a path for tumor growth and metastasis. C-X-C chemokine ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) is the key signaling for such aim. Gathering knowledge about the activity within this axis would deepen our insight into the utmost importance this signaling taken to attract and cross-connect multiple cells within the tumor microenvironment (TME) aiming for tumor progression and metastasis. The concept behind this review is to underscore the multi-tasking roles taken by CXCL12/CXCR4 signaling in tumor metastasis, and to also suggest some strategies to target the activities within this axis.
全文获取路径: Elsevier  (合作)
影响因子:2.555 (2012)

  • mediator 病媒动物
  • metastasis 同质蜕变
  • Cancer 巨蟹座
  • ligand 配合体
  • critical 临界的
  • solid 固体