Poly(N-isopropylacrylamide)-based dual-crosslinking biohybrid injectable hydrogels for vascularization
聚( N-异丙基丙烯酰胺)基双交联生物杂交可注射水凝胶用于血管化
作者: Amrita PalCameron I. SmithJoanna PaladeSupriya NagarajuByron A. Alarcon-BenedettoJacquelyn KilbourneAlan RawlsJeanne Wilson-RawlsBrent L. VernonMehdi Nikkhah
作者单位: 1School of Biological and Health Systems Engineering (SBHSE), Arizona State University, Tempe, AZ 85287, USA
2School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
3Department of Animal Care Technologies, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
4Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
刊名: Acta Biomaterialia, 2020, Vol.107 , pp.138-151
来源数据库: Elsevier Journal
DOI: 10.1016/j.actbio.2020.02.041
关键词: InjectableBiohybridDual crosslinkingHydrogelPoly(NIPAAm)Vasculogenic peptideVascularization
原始语种摘要: Abstract(#br)Injectable hydrogels provide a powerful and non-invasive approach for numerous applications in cell transplantation, growth factor delivery, tissue regeneration and so forth. The properties of injectable hydrogels should be well-tuned for specific applications, where their overall design should ensure biocompatibility, non-toxicity, robust mechanical properties, and most importantly the ability to promote vascularization and integration with the host tissue/organ. Among these criteria, vascularization remains a key design element in the development of functional therapeutic hydrogels for successful translation into clinical settings. To that end, there is still a critical need for the development of the next generation of injectable hydrogels with precisely tuned biophysical...
全文获取路径: Elsevier  (合作)
影响因子:5.093 (2012)

  • injectable 可注射的
  • crosslinking 交联
  • injectability 注入能力
  • peptide 
  • regenerative 再生放大
  • hydrogel 水凝胶
  • medicine 
  • mimetic 模仿的
  • developed 开发
  • properties 道具