Chronic Kidney Disease
作者: Michael S. Goligorsky
作者单位: 1Renal Research Institute, and the Departments of Medicine, Pharmacology, and Physiology, New York Medical College at Touro University, Valhalla, New York
刊名: The American Journal of Pathology, 2020, Vol.190 (6), pp.1164-1171
来源数据库: Elsevier Journal
DOI: 10.1016/j.ajpath.2020.01.016
英文摘要: Chronic kidney disease (CKD), commonly fostering nonrenal complications, themselves more life threatening than renal pathology, remains enigmatic. Despite more than a century of intense research, therapeutic options to halt or reverse renal disease are rather limited. Recently, similarity between manifestations of progressive CKD and aging kidney has attracted investigative attention that revealed senescent cells and secreting proinflammatory and profibrotic mediators in all renal compartments, even at young age, in patients with kidney maladies. The overlapping features of these categories have been noticed previously and are briefly summarized herein. I propose two hypothetical scenarios for interactive association of kidney diseases and cell senescence, both culminating in progressive...
全文获取路径: Elsevier  (合作)
影响因子:4.522 (2012)

  • Kidney