Immune gene expression in head and neck squamous cell carcinoma patients
作者: Charlotte LecerfMaud KamalSophie VacherWalid ChemlaliAnne SchnitzlerClaire MorelCoraline DubotEmmanuelle JeannotDidier MeseureJerzy KlijanienkoOdette MarianiEdith BorcomanValentin CalugaruNathalie BadoisAnne ChillesMaria LesnikSamar KrhiliOlivier ChoussyCaroline HoffmannEliane PiaggioIvan BiecheChristophe Le Tourneau
作者单位: 1Department of Drug Development and Innovation, Institut Curie, Paris & Saint-Cloud, France
2Department of Genetics, Institut Curie, PSL Research University, Paris, France
3Department of Pathology, Institut Curie, PSL Research University, Paris, France
4INSERM U932 Research Unit, Institut Curie, PSL Research University, Paris, France
5Department of Radiotherapy, Institut Curie, PSL Research University, Paris, France
6Department of Surgery, Institut Curie, PSL Research University, Paris, France
7EA7331, Paris Descartes University, Faculty of Pharmaceutical and Biological Sciences, Paris, France
8INSERM U900 Research Unit, Institut Curie, Saint-Cloud, France
9Versailles-Saint-Quentin-en-Yvelines University, Montigny-le-Bretonneux, France
刊名: European Journal of Cancer, 2019, Vol.121 , pp.210-223
来源数据库: Elsevier Journal
DOI: 10.1016/j.ejca.2019.08.028
关键词: Head and neck squamous cell carcinomaImmune checkpointsPrognostic biomarkerGene expression
原始语种摘要: Abstract(#br)Background(#br)Nivolumab and pembrolizumab targeting programmed cell death protein 1 (PD-1) have recently been approved among patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) who failed platinum therapy. We aimed to evaluate the prognostic value of selected immune gene expression in HNSCC.(#br)Patients and methods(#br)We retrospectively assessed the expression of 46 immune-related genes and immune-cell subpopulation genes including immune checkpoints by real-time polymerase chain reaction among 96 patients with HNSCC who underwent primary surgery at Institut Curie between 1990 and 2006. Univariate and multivariate analyses were performed to assess the prognostic value of dysregulated genes.(#br)Results(#br)The Median age of the...
全文获取路径: Elsevier  (合作)
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影响因子:5.061 (2012)

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关键词翻译
关键词翻译
  • squamous 具鳞的
  • carcinoma 癌症
  • expression 表示