Advances in the Masquelet technique: Myeloid-derived suppressor cells promote angiogenesis in PMMA-induced membranes
作者: Wenkai WangRui ZuoHaixia LongYanqiu WangYang ZhangChao SunGang LuoYuan ZhangChangqing LiYue ZhouJie Li
作者单位: 1Department of Orthopaedics, Xinqiao Hospital, Amy Medical University (Third Military Medical University), Chongqing, PR China
2Institute of Cancer, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, PR China
刊名: Acta Biomaterialia, 2020
来源数据库: Elsevier Journal
DOI: 10.1016/j.actbio.2020.03.010
关键词: Masquelet techniqueInduced membraneMyeloid-derived suppressor cells (MDSCs)Angiogenesis
原始语种摘要: Abstract(#br)The periosteum plays a critical role in bone formation and defect reconstruction. The concept of tissue engineering in the periosteum has been suggested to solve the clinical problems related to bone defect repair. Insertion of polymethyl methacrylate (PMMA) bone cement can induce the autologous generation of a tissue-engineered periosteum and has been considered as a promising strategy for bone defect reconstruction. The PMMA-induced membrane is a crucial element in the reconstruction of bone defects, especially for angiogenesis, but its biological mechanism remains elusive. Here, a PMMA-induced membrane model was established using a femoral critically sized defect in mice. We identified myeloid-derived suppressor cells (MDSCs) as a regulatory component of induced membrane...
全文获取路径: Elsevier  (合作)
影响因子:5.093 (2012)

  • induced 感应的
  • angiogenesis 血管生成
  • cells 麻风细胞
  • derived 导生的
  • suppressor 抑制栅
  • periosteum 骨膜
  • PMMA polymethyl methacrylate
  • membrane 
  • promote 助长
  • reconstruction 复原