Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration
低稳态氧化应激通过改变线粒体动力学和降低细胞呼吸抑制脂肪生成
作者: Raquel FernandoKristina WardelmannStefanie DeubelRichard KehmTobias JungMarco MariottiAphrodite VasilakiVadim N. GladyshevAndré KleinriddersTilman GruneJosé Pedro Castro
作者单位: 1Department of Molecular Toxicology, German Institute of Human Nutrition, Potsdam-Rehbrücke, 14558, Nuthetal, Germany
2German Center for Diabetes Research (DZD), 85764, München-Neuherberg, Germany
3German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Germany
4Central Regulation of Metabolism Group, German Institute of Human Nutrition, Potsdam-Rehbrücke, 14558, Nuthetal, Germany
5Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA
6MRC-Arthritis Research UK Centre for Integrated Research Into Musculoskeletal Ageing (CIMA), Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, UK
刊名: Redox Biology, 2020, Vol.32
来源数据库: Elsevier Journal
DOI: 10.1016/j.redox.2020.101507
关键词: AdipogenesisHyperoxiaOxidative stressMitochondrial dysfunctionRosiglitazone
英文摘要: Abstract(#br)Adipogenesis is a fundamental process of white adipose tissue function, supporting lipid storage and release, while avoiding its spillover and ectopic accumulation in tissues and organs. During aging adipogenesis is impaired and among other factors, oxidative stress contributes to this process. Adipogenesis requires functional and dynamic mitochondria; however, this organelle itself becomes dysfunctional during aging and accounts for most of reactive oxygen species (ROS) production. Here, we evaluated whether oxidative stress impairs adipogenesis through functional impairment of mitodynamics by utilizing hyperoxia as a continuous source of oxidative stress while maintaining cellular viability. This negatively impacted mitochondrial function, including respiration and dynamics...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • altering 修改
  • respiration 呼吸
  • adipogenesis 脂肪生成
  • steady 稳定的
  • oxidative 氧化的
  • state 状态
  • stress 应力
  • mitochondrial 线粒体的
  • cellular 细胞状的
  • decreasing 递减