Inherent fibrin fiber tension propels mechanisms of network clearance during fibrinolysis
作者: Sean J. ConeAndrew T. FuquayJustin M. LitofskyTaylor C. DementChristopher A. CarolanNathan E. Hudson
作者单位: 1Department of Physics, East Carolina University; 1000 E 5 th St, Greenville, NC 27858, United States
2Medical Physics Graduate Program, Duke University; DUMC 2729, 2424 Erwin Rd Suite 101, Durham, NC 27705, USA
3Department of Mathematics, East Carolina University; 1000 E 5 th St, Greenville, NC 27858, United States
刊名: Acta Biomaterialia, 2020, Vol.107 , pp.164-177
来源数据库: Elsevier Journal
DOI: 10.1016/j.actbio.2020.02.025
关键词: Fibrin(ogen)FibrinolysisPlasmin(ogen)ThrombosisHemostasis
原始语种摘要: Abstract(#br)Proper wound healing necessitates both coagulation (the formation of a blood clot) and fibrinolysis (the dissolution of a blood clot). A thrombus resistant to clot dissolution can obstruct blood flow, leading to vascular pathologies. This study seeks to understand the mechanisms by which individual fibrin fibers, the main structural component of blood clots, are cleared from a local volume during fibrinolysis. We observed 2-D fibrin networks during lysis by plasmin, recording the clearance of each individual fiber. We found that, in addition to transverse cleavage of fibers, there were multiple other pathways by which clot dissolution occurred, including fiber bundling, buckling, and collapsing. These processes are all influenced by the concentration of plasmin utilized in...
全文获取路径: Elsevier  (合作)
影响因子:5.093 (2012)

  • fibrin 纤维蛋白
  • clearance 间隙
  • during 在的期间
  • tension 张力
  • network 网络
  • inherent 固有的
  • fiber 纤维
  • equilibrium 平衡
  • individual 个体
  • understand 理解