Insulin-like growth factor-1 inhibits spreading depression-induced trigeminal calcitonin gene related peptide, oxidative stress & neuronal activation in rat
作者: Lisa WonRichard P. Kraig
作者单位: 1Department of Neurology, The University of Chicago, Chicago, IL 60637, United States
刊名: Brain Research, 2020, Vol.1732
来源数据库: Elsevier Journal
DOI: 10.1016/j.brainres.2020.146673
关键词: MigraineIntranasal deliveryCGRPTrigeminal ganglionTrigeminal nucleusOxidative stress
英文摘要: Abstract(#br)Migraineurs can show brain hyperexcitability and oxidative stress that may promote headache. Since hyperexcitability can enhance oxidative stress which promotes hyperexcitability, ending this feed-back loop may reduce migraine. Neocortical spreading depression, an animal model of migraine begins with hyperexcitability and triggers oxidative stress in the neocortical area involved and in the trigeminal system, which is important to pain pathway nociceptive activation in migraine. Additionally, oxidative stress causes increased trigeminal ganglion calcitonin gene-related peptide release and oxidative stress can reduce spreading depression threshold. Insulin-like growth factor-1 significantly protects against spreading depression in vitro by reducing oxidative stress and it is...
全文获取路径: Elsevier  (合作)
影响因子:2.879 (2012)

  • neuronal 二乙基溴乙酰胺
  • activation 活化
  • calcitonin 降钙素
  • stress 应力
  • trigeminal 三叉神经的
  • oxidative 氧化的
  • induced 感应的
  • depression 低地
  • peptide 
  • ganglion 脑神经节