Clinicopathological and prognostic significance of C/EBP homologous protein (CHOP) in advanced gastric cancer
作者: Xiangwen ZhangTingting ZhouWenbin LiTaotao ZhangNinwei CheGuo Zu
作者单位: 1Department of Gastroenterology Surgery, The Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116044, PR China
2Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, PR China
3Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, PR China
刊名: Pathology - Research and Practice, 2018, Vol.214 (8), pp.1105-1109
来源数据库: Elsevier Journal
DOI: 10.1016/j.prp.2018.06.005
关键词: Clinicopathological parametersPrognosisC/EBP homologous proteinGastric cancer
原始语种摘要: Abstract(#br)Background(#br)Few studies have reported the clinical and prognostic significance of C/EBP homologous protein (CHOP) in advanced gastric cancer (GC). Therefore, the present study investigated the expression of CHOP in advanced GC patients to determine its potential prognostic role.(#br)Methods(#br)The levels of CHOP in 95 patients with advanced GC and adjacent non-cancerous tissues were evaluated by qRT-PCR, western blot and immunohistochemistry. Furthermore, the association of CHOP expression with clinicopathological parameters and prognosis of advanced GC patients was analyzed.(#br)Results(#br)The levels of CHOP were down-regulated in advanced GC compared with non-cancerous tissues ( P <0.01). In addition, high CHOP expression more frequently occurred in advanced GC tissues...
全文获取路径: Elsevier  (合作)
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影响因子:1.213 (2012)

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关键词翻译
关键词翻译
  • advanced 先进的
  • gastric 胃的
  • prognostic 预测的
  • protein 蛋白质
  • cancerous 癌性的
  • homologous 同结构型的
  • survival 生存
  • significance 显著性
  • prognosis 预报
  • expression 表示