Cognitive behavioral therapy may have a rehabilitative, not normalizing, effect on functional connectivity in adolescent depression
作者: L.M. VillaI.M. GoodyerR. TaitR. KelvinS. ReynoldsP.O. WilkinsonJ. Suckling
作者单位: 1Department of Psychiatry, University of Cambridge, Herchel Smith Building, Robinson Way, Cambridge CB2 0SZ, United Kingdom
2Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom
3NIHR Cambridge Biomedical Research Centre, United Kingdom
4Cambridge and Peterborough NHS Foundation Trust, United Kingdom
5Faculty of Computing, Engineering and the Built Environment, Birmingham City University, United Kingdom
6The Royal College of Psychiatrists, United Kingdom
7The Association for Child and Adolescent Mental Health, United Kingdom
8School of Psychology and Clinical Language Sciences, University of Reading, United Kingdom
9Charlie Waller Institute, University of Reading, United Kingdom
刊名: Journal of Affective Disorders, 2020, Vol.268 , pp.1-11
来源数据库: Elsevier Journal
DOI: 10.1016/j.jad.2020.01.103
关键词: Adolescent depressionMRICBTCortical thicknessResting-state functional connectivityWhite matter volume
原始语种摘要: Abstract(#br)Background(#br)Whether the differences in brain structure and function, characteristic of adult major depressive disorder (MDD 1 1 Major Depressive Disorder (MDD). ), are present in adolescent MDD is still unclear, but it has been shown that cognitive behavioral therapy (CBT 2 2 Cognitive Behavioural Therapy (CBT). ) affects resting-state functional connectivity in both adult and adolescent MDD patients, with the claim that CBT has a normalizing effect on MDD-related functional disruption, but this has not been directly tested.(#br)Methods(#br)128 adolescent MDD patients and 40 adolescent controls were enrolled in the study. We investigated pre-treatment differences in cortical thickness, white matter volume, and resting-state functional connectivity. We also investigated the...
全文获取路径: Elsevier  (合作)
影响因子:3.295 (2012)

  • functional 功能的
  • adolescent 青年
  • connectivity 连通性
  • depression 低地
  • state 状态
  • normalizing 常火
  • related 有关的
  • disruption 破裂
  • resting 休息的
  • treatment 处理