Targeted next-generation sequencing identifies genomic abnormalities potentially driving the prognosis of early-stage invasive lobular breast carcinoma patients stratified according to a validated clinico-pathological model
靶向下一代测序确定基因组异常可能影响早期浸润性小叶乳腺癌患者的预后
作者: Luisa CarbogninMichele SimboloAnna CaliòCaterina VicentiniPietro DelfinoIsabella SperdutiMatteo FassanFrancesco SchettiniMaria Vittoria DieciGaia GriguoloSara PilottoElena FiorioGrazia ArpinoValentina GuarneriSabino De PlacidoPierfranco ConteErminia ManfrinMatteo BrunelliGiovanni ScambiaAldo ScarpaGiampaolo TortoraEmilio Bria
作者单位: 1University of Verona, Verona, Italy
2Division of Gynecologic Oncology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
3Department of Diagnostics and Public Health, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
4ARC-Net Research Centre and Department of Pathology, University of Verona, Verona, Italy
5Biostatistics, ‘Regina Elena’ National Cancer Institute, Roma, Italy
6Department of Medicine (DIMED), Surgical Pathology Unit, University of Padova, Padova, Italy
7Medical Oncology, Federico II University, Napoli, Italy
8Division of Medical Oncology 2, Istituto Oncologico Veneto, IRCCS, Padova, Italy
9Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy
10U.O.C. Medical Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
11Oncologia Medica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Del Sacro Cuore, Roma, Italy
刊名: The Breast, 2020, Vol.50 , pp.56-63
来源数据库: Elsevier Journal
DOI: 10.1016/j.breast.2020.01.034
关键词: Breast cancerLobularPrognosisNext-generation sequencingTranscriptome analysisCDK4
英文摘要: Abstract(#br)Introduction(#br)The clinico-pathological and molecular factors that drive the prognosis of invasive lobular breast carcinoma (ILC) are not entirely explored. In this regard, the development and validation of a prognostic model for ILC and the investigation of the distribution of molecular abnormalities (focusing on CDK4/6 alterations) according to prognosis were the aims of this study.(#br)Patients and methods(#br)Two clinico-pathological multi-center data-sets of early-stage ILC patients (Training/Validation Set, TS/VS) were gathered. A 3-class model was developed according to the multivariate analysis for disease-free-survival (DFS) and externally validated. Mutational, copy number variation and transcriptomic analyses by targeted next generation sequencing (NGS) were...
全文获取路径: Elsevier  (合作)
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影响因子:2.491 (2011)

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关键词翻译
关键词翻译
  • lobular 小裂片状的
  • potentially 可能地
  • prognosis 预报
  • pathological 病理学的
  • carcinoma 癌症
  • breast 胸部
  • invasive 侵入的
  • stage 
  • generation 世代
  • according 按照