Poor clinical outcomes of intratumoral dendritic cell–specific intercellular adhesion molecule 3–grabbing non-integrin–positive macrophages associated with immune evasion in gastric cancer
胃癌肿瘤内树突状细胞-特异性细胞间粘附分子3-抓取非整合素阳性巨噬细胞与免疫逃避的关系
作者: Xin LiuYifan CaoRuochen LiYong GuYifan ChenYangyang QiKunpeng LvJieti WangKuan YuChao LinHao LiuHeng ZhangHongyong HeLingli ChenPeipei ZhangZhenbin ShenJing QinYihong SunHe LiHua HuangWeijuan ZhangJiejie Xu
作者单位: 1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China
2Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
3Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China
4Department of Gastric Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China
5Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China
6Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
刊名: European Journal of Cancer, 2020, Vol.128 , pp.27-37
来源数据库: Elsevier Journal
DOI: 10.1016/j.ejca.2020.01.002
关键词: Gastric cancerTumour-associated macrophagesImmune evasionPrognosisAdjuvant chemotherapy
英文摘要: Abstract(#br)Aim(#br)Tumour-associated macrophages (TAMs) are prominent immune cells infiltrating in solid tumours with phenotypic and functional heterogeneity. However, the clinical significance of heterogeneous subtypes of TAMs in gastric cancer still remains obscure. Here, we aimed to explore the clinical significance of TAMs expressing dendritic cell–specific intercellular adhesion molecule 3–grabbing non-integrin (DC-SIGN) and its relevance with immune contexture in gastric cancer.(#br)Methods(#br)We selected 453 formalin-fixed and paraffin-embedded samples and 51 fresh tissue specimens of patients with gastric cancer from Zhongshan Hospital. The association of DC-SIGN + macrophages with clinicopathological parameters, overall survival (OS) and responsiveness to fluorouracil-based...
全文获取路径: Elsevier  (合作)
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影响因子:5.061 (2012)

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关键词翻译
关键词翻译
  • grabbing 抡夺
  • dendritic 师状的
  • immune 免疫的
  • evasion 规避
  • adhesion 粘附
  • molecule 分子
  • gastric 胃的
  • macrophages 巨噬细胞
  • associated 相关的
  • intercellular 细胞间的