IRE1α-targeting downregulates ABC transporters and overcomes drug resistance of colon cancer cells
作者: Qiang GaoXiu-xiu LiYi-ming XuJin-zhao ZhangShi-di RongYan-qing QinJing Fang
作者单位: 1Shanghai Institute of Nutrition and Health, Shanghai Institutes of Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
2Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao, 266061, China
3Cancer Institute, Qingdao University, Qingdao, 266061, China
刊名: Cancer Letters, 2020, Vol.476 , pp.67-74
来源数据库: Elsevier Journal
DOI: 10.1016/j.canlet.2020.02.007
关键词: IRE1αABC transporterDrug resistanceColon cancer
原始语种摘要: Abstract(#br)Drug resistance is a big problem in cancer treatment and one of the most prominent mechanisms underlain is overexpression of ATP-binding cassette (ABC) transporters, particularly ABCB1, ABCC1 and ABCG2. Inhibition of ABC transporters is an important approach to overcome drug resistance. The inositol-requiring enzyme 1α (IRE1α), an arm of unfolded protein response (UPR), splices XBP1 mRNA to generate an active transcription factor XBP1s. UPR is implicated in drug resistance. However, the underlying mechanism is unclear. We found that the anticancer drugs such as 5-fluorouracil (5-FU) activated the IRE1α-XBP1 pathway to induce the expression of ABCB1, ABCC1 and ABCG2 in colon cancer cells. Inhibition of IRE1α RNase activity with small molecule 4μ8c suppressed the drug-induced...
全文获取路径: Elsevier  (合作)
影响因子:4.258 (2012)

  • targeting 导向目标
  • colon 结肠
  • cells 麻风细胞
  • cancer 癌症
  • resistance 抵抗
  • ABC ABC automatic coding system