Psychometric Analysis of the Abdominal Score From the Diary for Irritable Bowel Syndrome Symptoms–Constipation Using Phase IIb Clinical Trial Data
作者: Cheryl D. CoonJennifer HanlonJessica L. AbelJ. Jason LundyRobyn T. CarsonDavid S. Reasner
作者单位: 1Outcometrix, St Petersburg, FL, USA
2Ironwood Pharmaceuticals, Inc, Boston, MA, USA
3Allergan plc, Madison, NJ, USA
4Imbria Pharmaceuticals, Boston, MA, USA
刊名: Value in Health, 2020, Vol.23 (3), pp.362-369
来源数据库: Elsevier Journal
DOI: 10.1016/j.jval.2020.01.002
关键词: Diary for Irritable Bowel Syndrome Symptoms–ConstipationIrritable bowel syndromePsychometric analysis
英文摘要: Abstract(#br)Objectives(#br)The Diary for Irritable Bowel Syndrome Symptoms–Constipation (DIBSS-C) has been developed to assess the core signs and symptoms of irritable bowel syndrome with constipation (IBS-C). This article presents the psychometric evaluation of the DIBSS-C abdominal score.(#br)Methods(#br)Data for these analyses are from a multicenter phase IIb study in IBS-C patients (NCT02559206). Subjects completed a number of assessments via handheld electronic diary throughout the study. The analyses used the intent-to-treat population and were blinded to randomized treatment group. The analyses evaluated the reliability, validity, and responsiveness of the DIBSS-C abdominal score; identified an appropriate scoring algorithm; and determined thresholds for interpreting clinically...
全文获取路径: Elsevier  (合作)
影响因子:2.191 (2012)

  • Data 数据
  • Analysis 分析