Differential regulation of Nrf2 is linked to elevated inflammation and nitrative stress in monocytes of children with autism
作者: Ahmed NadeemSheikh F. AhmadLaila Y. AL-AyadhiSabry M. AttiaNaif O. Al-HarbiKhalid S. AlzahraniSaleh A. Bakheet
作者单位: 1Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
2Autism Research and Treatment Center, AL-Amodi Autism Research Chair, Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
刊名: Psychoneuroendocrinology, 2020, Vol.113
来源数据库: Elsevier Journal
DOI: 10.1016/j.psyneuen.2019.104554
关键词: AutismNrf2InflammationNitrative stressSulforaphaneMonocytes
原始语种摘要: Abstract(#br)Autism spectrum disorder (ASD) is a very complex neurodevelopmental disorder characterized by deficits in social and communication skills. Innate immune cells like monocytes are believed to play a cardinal role in neuroimmune inflammation and nitrative stress. On the other hand, Nrf2, a basic leucine zipper transcription factor plays a significant role in protecting the immune cells against inflammation and oxidants. However, its role in monocytes of ASD children and typically developing control (TDC) children has not been elucidated in relation with inflammation and nitrative stress. Therefore, this study was undertaken to evaluate Nrf2 expression/activity along with parameters of inflammation (NF k B, IL-6, IL-1β) and nitrative stress (iNOS, nitrotyrosine) in monocytes of...
全文获取路径: Elsevier  (合作)
影响因子:5.137 (2012)

  • inflammation 炎症
  • monocytes 单核细胞
  • stress 应力
  • autism 孤独症
  • immune 免疫的
  • elevated 高的
  • transcription 地名转写
  • LPS Laboratory Peripheral System
  • autistic 我向的
  • regulation