CHL1 promotes insulin secretion and negatively regulates the proliferation of pancreatic β cells
作者: Hemin JiangYuwei LiuYu QianZiyang ShenYunqiang HeRui GaoMin ShenShu ChenQi FuTao Yang
作者单位: 1Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
刊名: Biochemical and Biophysical Research Communications, 2020, Vol.525 (4), pp.1095-1102
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbrc.2020.03.040
关键词: CHL1Pancreatic isletsΒ cellsInsulin secretionCell proliferationERK
英文摘要: Abstract(#br)Cell adhesion molecule L1-like protein (CHL1) is a member of neural recognition molecules of immunoglobulin superfamily primarily expressing in the nervous system. CHL1 regulates neuronal migration, axonal growth, and dendritic projection. Downregulation of CHL1 has been reported in β cells of patients with type 2 diabetes (T2DM). However, the detailed role of CHL1 in β cells has not been characterized. In this study, Real-Time PCR and Western blot were applied to investigate the tissue/cell distribution and expression of CHL1. Gain- or loss-of function studies were conducted in MIN6 cells to determine the effects of CHL1 on cell proliferation, apoptosis, cell cycle, and insulin secretion. Following silencing of CHL1 in MIN6 cells (si-CHL1), insulin secretion and the number...
全文获取路径: Elsevier  (合作)

  • insulin 胰岛素
  • negatively 否定地
  • secretion 分泌
  • cells 麻风细胞
  • pancreatic 胰的
  • proliferation 增生