Immunomodulatory activity of low molecular-weight peptides from Nibea japonica skin in cyclophosphamide-induced immunosuppressed mice
作者: Fangmiao YuKang HeXiaoze DongZhuangwei ZhangFenglei WangYunping TangYan ChenGuofang Ding
作者单位: 1Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China
刊名: Journal of Functional Foods, 2020, Vol.68
来源数据库: Elsevier Journal
DOI: 10.1016/j.jff.2020.103888
关键词: Nibea japonicaProtein hydrolysatesLow molecular-weight peptideImmunosuppressed miceImmunomodulatory
英文摘要: Abstract(#br)In this study, a low molecular weight peptides fraction (<3 kDa, named NJSP) was isolated and purified from the skin protein hydrolysate of Nibea japonica by ultrafiltration. The in vivo immunomodulatory effects of NJSP were investigated in cyclophosphamide (CY)-induced immunosuppressed mice. The intragastric administration of NJSP (100, 200, 400 mg/kg/d) upregulated the immune organ indexes, restored the pathological histomorphology of immune organs, and improved the body weight of CY-treated mice in a time and dose-dependent manner. NJSP treatment also remarkably promoted the proliferation of splenocyte, enhanced phagocytosis of macrophages, restored delayed-type hypersensitivity (DTH). Moreover, NJSP administration dramatically improved hemolysin, tumor necrosis factor α...
全文获取路径: Elsevier  (合作)
影响因子:2.632 (2012)

  • japonica 海带
  • weight 
  • induced 感应的
  • molecular 分子的
  • activity 活度
  • peptide