The Impact of Age and Gender on Outcomes of Patients With Advanced Renal Cell Carcinoma Treated With Targeted Therapy
作者: Justine PanianXun LinRonit SimantovIthaar DerweeshToni K. ChoueiriRana R. McKay
作者单位: 1Department of Medicine, Division of Hematology/Oncology, University of California San Diego, Moores Cancer Center, La Jolla, CA
2Pfizer Oncology, New York, NY
3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
刊名: Clinical Genitourinary Cancer, 2020
来源数据库: Elsevier Journal
DOI: 10.1016/j.clgc.2020.03.010
关键词: ElderyKidney cancerPrognosisSurvivalYoung
原始语种摘要: Abstract(#br)Background(#br)A growing body of evidence suggests that age and gender play a role in cancer outcomes. The objective of this study was to investigate the effect of age and gender on survival of patients with metastatic renal cell carcinoma (RCC).(#br)Methods(#br)We conducted a pooled analysis of patients with metastatic RCC treated on phase II and III clinical trials. Patients were stratified by age (young [<50 years], intermediate [50-70 years], versus elderly [>70 years]) and gender. Statistical analyses were performed using Cox regression adjusted for several risk factors and the Kaplan-Meier method.(#br)Results(#br)We identified 4736 patients with metastatic RCC. Overall, there was no difference in overall survival (OS) when stratified by age (21.0 vs. 17.3 months for...
全文获取路径: Elsevier  (合作)
影响因子:1.429 (2012)