Intraoperative flow cytometry for head and neck lesions. Assessment of malignancy and tumour-free resection margins
作者: George VartholomatosLentiona BasiariGeorge ExarchakosIoannis KastanioudakisIoannis KomnosMaria MichaliGeorgios S. MarkopoulosAnna BatistatouAlexandra Papoudou-BaiGeorge A. Alexiou
作者单位: 1Haematology Laboratory – Unit of Molecular Biology, University Hospital of Ioannina, Greece
2Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Ioannina, Greece
3Laboratory of Biology, Department of Medicine, Faculty of Medicine, School of Health Sciences, Ioannina, Greece
4Department of Pathology, University Hospital of Ioannina, Greece
5Department of Neurosurgery, University Hospital of Ioannina, Greece
刊名: Oral Oncology, 2019, Vol.99
来源数据库: Elsevier Journal
DOI: 10.1016/j.oraloncology.2019.06.025
关键词: Flow cytometryIntraoperativeHead and neck neoplasmsMargins of excisionAneuploidy
原始语种摘要: Abstract(#br)Head and neck cancer poses a significant health problem worldwide. We set out to investigate the value of rapid intraoperative cell cycle analysis by flow cytometry for the intraoperative characterization of head and neck lesions and surgical margins. Seventy patients with head and neck lesions suspicious of malignancy were included in the study. There were 31 neoplastic and 39 benign lesions. Flow cytometry permitted the intraoperative detection of neoplastic lesions within 6 min with high sensitivity and specificity based on cell cycle fractions. In the cases in which surgical margins were assessed, intraoperative flow cytometry had complete concordance with pathology. Intreoperative flow cytometry is a novel promising technique for rapid intraoperative characterization of...
全文获取路径: Elsevier  (合作)
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影响因子:2.695 (2012)

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关键词翻译
关键词翻译
  • malignancy 恶性
  • resection 后方交会
  • tumour 肿瘤
  • cytometry 血细胞计数
  • excision 切除
  • neoplasms 新生物
  • margins 片边