Toxicity of silver nanoparticles on wound healing: A case study of zebrafish fin regeneration model
作者: Shaochen PangYue GaoFengbang WangYuanyuan WangMengxi CaoWenjuan ZhangYong LiangMaoyong SongGuibin Jiang
作者单位: 1Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Jianghan University, Wuhan 430056, China
2Key Laboratory of Environmental Nanotechnology and Health Effects, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
3Institute of Environment and Health, Jianghan University, Wuhan 430056, China
4University of Chinese Academy of Sciences, Beijing 100049, China
刊名: Science of the Total Environment, 2020, Vol.717
来源数据库: Elsevier Journal
DOI: 10.1016/j.scitotenv.2020.137178
关键词: AgNPsEpithelializationProliferationNeutrophilReactive oxygen species
英文摘要: Abstract(#br)Dressings coated with silver nanoparticle (AgNP) are widely used in the management of acute and chronic wounds. However, whether AgNP exerts toxicity on wound healing remains ambiguous. To demonstrate the effects of AgNP on wound healing, we precisely quantified the recovery speed of wound by taking advantage of the fin regeneration of zebrafish. This method also enabled assessment of the adverse effect of AgNP on various steps of wound healing in vivo . We revealed that AgNP treatment at the concentration of 2 μg/ml impaired fin regeneration when exposure was performed at the phases of epithelialization and the beginning of blastema formation. Cell proliferation of regenerative blastema was significantly decreased after AgNP exposure. But the canonical signals including...
全文获取路径: Elsevier  (合作)
影响因子:3.258 (2012)

  • silver 
  • regeneration 再生
  • oxygen 
  • study 学习
  • healing 加硫
  • species 
  • wound 
  • model 模型