Current Concepts of Osteomyelitis
作者: Marloes I. HofsteeGowrishankar MuthukrishnanGerald J. AtkinsMartijn RioolKeith ThompsonMario MorgensternMartin J. StoddartRobert G. RichardsSebastian A.J. ZaatThomas F. Moriarty
作者单位: 1AO Research Institute Davos, Davos, Switzerland
2Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, the Netherlands
3Center for Musculoskeletal Research and Department of Orthopaedics, University of Rochester Medical Center, Rochester, New York
4Centre for Orthopaedic and Trauma Research, University of Adelaide, Adelaide, South Australia, Australia
5Department of Orthopedic Surgery and Traumatology, University Hospital Basel, Basel, Switzerland
刊名: The American Journal of Pathology, 2020, Vol.190 (6), pp.1151-1163
来源数据库: Elsevier Journal
DOI: 10.1016/j.ajpath.2020.02.007
英文摘要: Osteomyelitis is an inflammation of the bone and bone marrow that is most commonly caused by a Staphylococcus aureus infection. Much of our understanding of the underlying pathophysiology of osteomyelitis, from the perspective of both host and pathogen, has been revised in recent years, with notable discoveries including the role played by osteocytes in the recruitment of immune cells, the invasion and persistence of S. aureus in submicron channels of cortical bone, and the diagnostic role of polymorphonuclear cells in implant-associated osteomyelitis. Advanced in vitro cell culture models, such as ex vivo culture models or organoids, have also been developed over the past decade, and have become widespread in many fields, including infectious diseases. These models better mimic the in...
全文获取路径: Elsevier  (合作)
影响因子:4.522 (2012)