The α1-adrenoceptor-mediated human hyperplastic prostate cells proliferation is impaired by EGF receptor inhibition
作者: Jessica Barbosa Nascimento-VianaRocío Alcántara-HernándezEliane Oliveira-BarrosLuiza A. Castello BrancoPriscilla R. FeijóLuiz Antonio Soares RomeiroLuiz Eurico NasciuttiFrançois NoëlJ. Adolfo García-SáinzClaudia Lucia Martins Silva
作者单位: 1Laboratory of Biochemical and Molecular Pharmacology, Universidade Federal do Rio de Janeiro, Brazil
2Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico
3Cell Biology and Development Research Program, Universidade Federal do Rio de Janeiro, Brazil
4Pharmaceutical Sciences, Universidade de Brasília, Brazil
刊名: Life Sciences, 2019, Vol.239
来源数据库: Elsevier Journal
DOI: 10.1016/j.lfs.2019.117048
关键词: AdrenoceptorBenign prostatic hyperplasiaEGFN-phenylpiperazine
原始语种摘要: Abstract(#br)Benign prostatic hyperplasia (BPH) is an aging-related and progressive disease linked to an up-regulation of α 1 -adrenoceptors. The participation of EGF receptors (EGFR) in the GPCRs’ signalosome has been described but so far data about the contribution of these receptors to prostatic stromal hyperplasia are scanty. We isolated and cultured vimentin-positive prostate stromal cells obtained from BPH patients. According to intracellular Ca 2+ measurements, cell proliferation and Western blotting assays, these cultured hyperplastic stromal cells express functional α 1- adrenoceptors and EGFR, and proliferate in response to the α 1- adrenoceptor agonist phenylephrine. Interestingly, in these cells the inhibition of EGFR signaling with GM6001, CRM197, AG1478 or PD98059 was...
全文获取路径: Elsevier  (合作)
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影响因子:2.555 (2012)

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关键词翻译
关键词翻译
  • hyperplastic 境生的
  • prostate 前列腺
  • adrenoceptor 肾上腺素能受体
  • impaired 受损
  • receptor 接受体
  • inhibition 抑制
  • EGF 表皮生长因子
  • cells 麻风细胞
  • proliferation 增生
  • human 人的