Particulate matter air pollution and the expression of microRNAs and pro-inflammatory genes: Association and mediation among children in Jinan, China
作者: Jie LiTing WangYanhua WangMengmeng XuLiping ZhangXinwei LiZhong LiuSheng GaoQiang JiaYaochun FanZhenjie WangNan WuXiao ZhangYufei DaiFanling KongWenrui WangHuawei Duan
作者单位: 1National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
2Key Laboratory of Chemical Safety and Health, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China
3Jinan Municipal Center for Disease Control and Prevention, Jinan, China
4Inner Mongolia Center for Disease Control and Prevention, Hohhot, China
5Shandong Academy of Occupational Health and Occupational Medicine, Jinan, China
6Shandong Center for Disease Control and Prevention, Jinan, China
刊名: Journal of Hazardous Materials, 2020, Vol.389
来源数据库: Elsevier Journal
DOI: 10.1016/j.jhazmat.2019.121843
关键词: Particulate matterChildrenInflammationMicroRNA
原始语种摘要: Abstract(#br)Exposure to particulate matter (PM) has been associated with increased risk of various diseases, possibly through its effect on inflammatory response. MicroRNAs (miRNAs), an epigenetic mechanism regulating gene expression, can affect the expression of pro-inflammatory genes. However, few epidemiological studies have examined the impact of PM on inflammation-related miRNAs and their target mRNAs, especially among vulnerable population. We recruited 160 and 113 children from areas with different PM level in Jinan, China. We measured benzo[a]pyrene-r-7,t-8,t-9,c-10-tetrahydotetrol-albumin (BPDE-Alb) adducts in serum and the expression of 5 candidate miRNAs involved in inflammation regulation and 7 pro-inflammatory genes predicted to be their targets in leukocytes. Generally,...
全文获取路径: Elsevier  (合作)
影响因子:3.925 (2012)

  • expression 表示
  • China 中国
  • among 在当中
  • inflammatory 激怒的
  • matter 物质
  • lower 降下
  • increased 增加
  • higher 
  • possibly 无论如何
  • mediation